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DKFZ-633

Chemical Structure : DKFZ-633

CAS No.: 2244425-14-5

DKFZ-633 (DKFZ633;DKFZ 633)

Catalog No.: PC-35660Not For Human Use, Lab Use Only.

DKFZ-633 (DKFZ633) is a selective inhibitor of Kallikrein-related peptidase 6 (KLK6) with IC50 of 0.25 uM, demonstrates good selectivity for KLK6 compared to other KLKs.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DKFZ-633 (DKFZ633) is a selective inhibitor of Kallikrein-related peptidase 6 (KLK6) with IC50 of 0.25 uM, demonstrates good selectivity for KLK6 compared to other KLKs.
    DKFZ-633 is a useful chemical probe to pull down active endogenous KLK6.

    Physicochemical Properties

    M.Wt 440.503
    Formula C26H24N4O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-((3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)amino)-2-oxoethyl 2-(5-ethynyl-2-methyl-1H-indol-3-yl)acetate

    References

    1. De Vita E, et al. J Med Chem. 2018 Sep 28. doi: 10.1021/acs.jmedchem.8b01106.

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