Chemical Structure : DLG-41
CAS No.:
DLG-41
Catalog No.: PC-25799Not For Human Use, Lab Use Only.
DLG-41 is a potent, selective inhibitor of GAS41 YEATS domain with IC50 of 610 nM in in AlphaLISA assays, binds to GAS41 YEATS domain with ITC KD of 1.0 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DLG-41 is a potent, selective inhibitor of GAS41 YEATS domain with IC50 of 610 nM in in AlphaLISA assays, binds to GAS41 YEATS domain with ITC KD of 1.0 uM.
DLG-41 blocks binding of GAS41 with chromatin in HEK293T cells with IC50 of 0.9 uM, with no activity for BRD4-BD1.
DLG-41 blocks proliferation of a panel of NSCLC cell lines in a GAS41 dependent manner (H1299 cell IC50=0.45 uM).
DLG-41 decreases global gene expression and ameliorates NSCLC phenotypes in H1299 cells, associated with lung cancer cell identity, tumor migration, and invasion.
Physicochemical Properties
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M.Wt
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601.78
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Formula
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C32H35N5O3S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-4,4-Dimethyl-N-(5-(3-(5-(4-(propionamidomethyl)naphthalen-1-yl)thiazol-2-yl)azetidine-1-carbonyl)thiophen-2-yl)pyrrolidine-2-carboxamide
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References
1. Listunov D, et al. J Med Chem. 2025 Nov 26. doi: 10.1021/acs.jmedchem.5c02307.
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