DNA polymerase theta inhibitor | POLθ inhibitor

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Chemical Structure : DNA polymerase theta inhibitor

DNA polymerase theta inhibitor (POLθi)

Catalog No.: PC-20598Not For Human Use, Lab Use Only.

DNA polymerase theta inhibitor (POLθi) is a small-molecule DNA polymerase theta (POLθ) inhibitor, binds to an allosteric pocket in the thumb subdomain of POLθ, inhibits its polymerase activity.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DNA polymerase theta inhibitor (POLθi) is a small-molecule DNA polymerase theta (POLθ) inhibitor, binds to an allosteric pocket in the thumb subdomain of POLθ, inhibits its polymerase activity.

Physicochemical Properties

M.Wt	433.51
Formula	C24H27N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(NC1=CC=C(C)N=C1)NC2=NC(C3=CC=C(OCC4(C)COCC4)C(C)=C3)=CN=C2

References

1. Anna Schrempf, et al. Cell Rep. 2022 Nov 29;41(9):111716.

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