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Chemical Structure : DPI 201-106
CAS No.: 97730-95-5
Catalog No.: PC-38569Not For Human Use, Lab Use Only.
DPI 201-106 (SDZ 201106) is a positive inotropic agent that prolongs the open state of cardiac voltage-gated Na+ channels.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $158 | In stock | |
| 100 mg | $358 | In stock | |
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DPI 201-106 (SDZ 201106) is a positive inotropic agent that prolongs the open state of cardiac voltage-gated Na+ channels.
DPI 201-106 produced concentration-dependent positive inotropic effects in guinea-pig and rat left atria, kitten, rabbit and guinea-pig papillary muscles and Langendorff perfused hearts of rabbits between 0.1-3 uM.
DPI 201-106 increased the Ca2+-sensitivity of skinned fibres from porcine trabecula septomarginalis with EC50 of 0.2 nM.
DPI (1-100 uM) suppressed the amplitude of delayed-rectifier K+ current (I(K(DR))) in a concentration-dependent manne with IC50 of 6.4 uM.
DPI-201106 also selectively reverses ABCB1-mediated multidrug resistance in cancer cell lines.
| M.Wt | 466.58 | |
| Formula | C29H30N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-[3-[4-(Diphenylmethyl)-1-piperazinyl]-2-hydroxypropoxy]-1H-indole-2-carbonitrile |
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1. Scholtysik G, et al. Naunyn Schmiedebergs Arch Pharmacol. 1985 May;329(3):316-25.
2. Buggisch D, et al. Eur J Pharmacol. 1985 Dec 3;118(3):303-11.
3. Scholtysik G, et al. Eur J Pharmacol. 1986 Jun 5;125(1):111-8.
4. Hsiao SH, et al. Cancer Lett. 2018 Oct 10;434:81-90.
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