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Chemical Structure : DRB18
CAS No.: 2863686-81-9
Catalog No.: PC-72387Not For Human Use, Lab Use Only.
DRB18 (DRB-18) is a potent, pan-class I glucose transporter (GLUT) inhibitor, reduces glucose uptake in HEK293 cell lines expressd single GLUT1-4 with IC50 of 0.9-8.8 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $368 | In stock | |
| 25 mg | $568 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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DRB18 (DRB-18) is a potent, pan-class I glucose transporter (GLUT) inhibitor, reduces glucose uptake in HEK293 cell lines expressd single GLUT1-4 with IC50 of 0.9-8.8 uM.
DRB18 reduced cell viability in a dose-dependent manner in cancer cell lines (A549 IC50=3.5 uM, HeLa IC50=1.3 uM), also exhibited IC50 values < 10 μM in all nine melanoma cell lines.
DRB18 rapidly and potently inhibited glucose transport and glucose metabolism, inhibited multiple metabolic pathways associated with glucose metabolism in A549 cells.
DRB18 caused G1/S phase arrest and increased oxidative stress in A549 cells.
DRB18 (10mg/kg) inhibited the growth of A549 tumors xenografted in nude mice.
| M.Wt | 382.888 | |
| Formula | C22H23ClN2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5,5'-(((4-chloro-1,2-phenylene)bis(azanediyl))bis(methylene))bis(2-methylphenol) |
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1. Shriwas P, et al. Cancer Metab. 2021 Mar 26;9(1):14.
2. Roberts DA, et al. Bioorg Med Chem Lett. 2020 Sep 15; 30(18):127406.
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