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Chemical Structure : DS-1211
Catalog No.: PC-49299Not For Human Use, Lab Use Only.
DS-1211 (DS1211) is a potent, selecitve inhibitor of tissue-nonspecific alkaline phosphatase (TNAP) with IC50 of 3.4 nM.
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DS-1211 (DS1211) is a potent, selecitve inhibitor of tissue-nonspecific alkaline phosphatase (TNAP) with IC50 of 3.4 nM.
DS-1211 displays >400-fold selectivity over intestinal alkaline phosphatase (IAP) and placental alkaline phosphatase (PLAP), also shows no significant response(≥50% inhibition) on a total of 88 receptors, channels, transporters, and enzymes.
DS-1211 exhibits TNAP selectivity and potent inhibition of TNAP across species.
DS-1211 inhibits ALP activity through an uncompetitive mode of action.
DS-1211 effetively inhibits mouse, monkey, and human plasma alkaline phosphatase with IC50 of 13.3, 36.3 and 28.3 nM, respectively.
Single oral administration of DS-1211 showed linear pharmacokinetics, with dose-dependent inhibition of ALP activity, and increases in plasma PPi and PLP in vivo.
| M.Wt | 367.351 | |
| Formula | C15H14FN3O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Soma K, et al. J Bone Miner Res. 2022 Aug 23. doi:10.1002/jbmr.4680.
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