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Chemical Structure : DS-1971a
CAS No.: 1450595-86-4
Catalog No.: PC-72189Not For Human Use, Lab Use Only.
DS-1971a (DS1971a) is a highly potent, selective NaV1.7 inhibitor with IC50 of 22.8 nM (hNaV1.7) and 59.4 nM (mNaV1.7).
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|---|---|---|---|
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| 25 mg | $598 | In stock | |
| 100 mg | $1280 | In stock | |
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| 1 g | Get quote |
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DS-1971a (DS1971a) is a highly potent, selective NaV1.7 inhibitor with IC50 of 22.8 nM (hNaV1.7) and 59.4 nM (mNaV1.7).
DS-1971a displays weak inhibitory activity against hNaV1.2 (IC50=1960 nM) and hNaV1.6 (IC50=495 nM), superior selectivity against hNaV1.1 and hNaV1.5 (IC50 values >100 uM).
DS-1971a shows a 10-fold higher potency than PF-05089771 using animal models of neuropathic pain.
| M.Wt | 465.928 | |
| Formula | C20H21ClFN5O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-chloro-2-fluoro-4-(((1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl)oxy)-N-(pyrimidin-4-yl)benzenesulfonamide |
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1. Shinozuka T, et al. J Med Chem. 2020 Sep 24;63(18):10204-10220.
2. Asano D, et al. Xenobiotica. 2021 Sep;51(9):1060-1070.
3. Asano D, et al. Drug Metab Dispos. 2021 Dec 20:DMD-AR-2021-000665.
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