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Chemical Structure : DS-3032 tosylate hydrate
CAS No.: 2095625-97-9
Catalog No.: PC-21238Not For Human Use, Lab Use Only.
Milademetan (DS-3032b) is a potent, selective, orally available MDM2-p53 inhibitor with potential antineoplastic activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $258 | In stock | |
| 5 mg | $458 | In stock | |
| 10 mg | $758 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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Milademetan (DS-3032b) is a potent, selective, orally available MDM2-p53 inhibitor with potential antineoplastic activity.
Milademetan (DS-3032b) binds to, and prevents the binding of MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53.
Milademetan (DS-3032b) restores p53 signaling and leads to the p53-mediated induction of tumor cell apoptosis.
| M.Wt | 790.73 | |
| Formula | C37H42Cl2FN5O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3'R,4'S,5'R)-N-((3R,6S)-6-carbamoyltetrahydro-2H-pyran-3-yl)-6''-chloro-4'-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamide 4-methylbenzenesulfonate |
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1. Ishizawa J, et al. Cancer Res. 2018 May 15;78(10):2721-2731.
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