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Chemical Structure : DS-5272
Catalog No.: PC-60481Not For Human Use, Lab Use Only.
A potent and orally active p53-MDM2 interaction inhibitor with IC50 of 2.4 nM.
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A potent and orally active p53-MDM2 interaction inhibitor with IC50 of 2.4 nM; inhibits SJSA-1 cell proliferation with GI50 of 0.17 uM, demonstrates excellent antitumor efficacy on SJSA-1 xenografted models with high safety and good PK profiles.
| M.Wt | 703.675 | |
| Formula | C34H38Cl2F2N6O2S | |
| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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1. Miyazaki M, et al. Bioorg Med Chem. 2015 May 15;23(10):2360-7.
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