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Chemical Structure : DS68591889
CAS No.: 2488609-21-6
Catalog No.: PC-21523Not For Human Use, Lab Use Only.
DS68591889 (PTDSS1i) is a potent, selective phosphatidylserine synthase 1 (PTDSS1) inhibitor, highly sellective over PTDSS2, induces phospholipid imbalance in a wide range of cancer cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $398 | In stock | |
| 5 mg | $558 | In stock | |
| 10 mg | Get quote | ||
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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DS68591889 (PTDSS1i) is a potent, selective phosphatidylserine synthase 1 (PTDSS1) inhibitor, highly sellective over PTDSS2, induces phospholipid imbalance in a wide range of cancer cells.
DS68591889 (PTDSS1i) (1 uM) caused a substantial loss of PS and phosphatidylethanolamine, along with a slight decrease in phosphatidylglycerol (PG) and sphingomyelin (SM) and an increase in phosphatidic acid (PA) in Hela cells.
DS68591889 (PTDSS1i) (10, 30, or 100 mg/kg, oral) suppressed Jeko-1 cell engraftment in the bone marrow in B cell lymphoma in vivo.
DS68591889 (PTDSS1i) negatively regulates BCR-induced Ca2+ signaling and cell death, does not overtly affect the morphology of organelles, cell surface expression of BCR signaling components, or BCR-induced phosphorylation of downstream molecules.
DS68591889 (PTDSS1i) efficiently suppressed tumor growth and prolonged survival in mouse xenograft model.
| M.Wt | 600.50 | |
| Formula | C29H21F5N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
7-(5-(2,2-difluoropropyl)-4-(4-(3-methyl-4-(trifluoromethoxy)phenoxy)phenyl)-6-oxo-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzo[d]oxazol-2(3H)-one |
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1. Jumpei Omi, et al. J Cell Biol. 2024 Feb 5;223(2):e202212074.
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