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DS79182026

Chemical Structure : DS79182026

CAS No.: 2113642-80-9

DS79182026 (DS 79182026;DS-79182026)

Catalog No.: PC-61013Not For Human Use, Lab Use Only.

DS79182026 (DS-79182026) is a potent, orally active hepcidin production inhibitor with IC50 of 39 nM, with low kinase inhibitory activity.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DS79182026 (DS-79182026) is a potent, orally active hepcidin production inhibitor with IC50 of 39 nM, with low kinase inhibitory activity; inhibits hepcidin production in HepG2 cell, slowers serum hepcidin in mouse IL-6 induced acute inflammatory model.

Physicochemical Properties

M.Wt 349.35
Formula C18H15N5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

methyl (6-(5-methyl-3-(pyridin-2-yl)-1H-pyrazol-4-yl)benzo[d]isoxazol-3-yl)carbamate

References

1. Fukuda T, et al. Bioorg Med Chem Lett. 2017 Aug 15;27(16):3716-3722.

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