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Chemical Structure : DSO-5a
Catalog No.: PC-20957Not For Human Use, Lab Use Only.
DSO-5a (Dimethyl shikonin oxime 5a) is a potent, selective agonist pf bombesin receptor subtype-3 (BB3, BRS-3) with pEC50 of 8.4 (IP-1 accumulation in hBB3-H1299 cells).
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DSO-5a (Dimethyl shikonin oxime 5a) is a potent, selective agonist pf bombesin receptor subtype-3 (BB3, BRS-3) with pEC50 of 8.4 (IP-1 accumulation in hBB3-H1299 cells).
DSO-5a did not elicit detectable calcium response in parental cells but elicited a strong calcium response in hBB3-H1299 cells with a pEC50 value of 7.964, Bantag-1 blocked these calcium responses in a dose-dependent manner.
DSO-5a induced a dose-dependent IP-1 accumulation with a pEC50 value of 7.262 in mBB3-HEK cells.
DSO-5a elicited IP-1 accumulation with pEC50 value of 9.357 in B16 cells.
DSO-5a (3 mg/kg; 10 mg/kg; 30 mg/kg) 30 min before glucose challenge (3 g/kg) reduced blood glucose excursions in a dose-dependent manner in C57BL/6 mice.
| M.Wt | 440.45 | |
| Formula | C23H24N2O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lehao Wu, et al. J Med Chem. 2023 Jun 22;66(12):8011-8029.
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