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Chemical Structure : DSP-1053
Catalog No.: PC-63256Not For Human Use, Lab Use Only.
DSP-1053 is a novel potent serotonin reuptake (SERT) inhibitor with 5-HT1A partial agonistic activity that binds to human serotonin transporter and 5-HT1A receptor with Ki of 1.02 and 5.05 nM, respectively.
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DSP-1053 is a novel potent serotonin reuptake (SERT) inhibitor with 5-HT1A partial agonistic activity that binds to human serotonin transporter and 5-HT1A receptor with Ki of 1.02 and 5.05 nM, respectively; inhibits serotonin transporter with IC50 of 2.74 nM and shows an intrinsic activity for 5-HT1A receptors of 70.0%; dose-dependently increases extracellular 5-HT levels in rat microdialysis at 3-10 mg/kg, demonstrates antidepressant-like effect in vivo.
Depression
Phase 1 Discontinued
| M.Wt | 660.62 | |
| Formula | C32H38BrNO7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yoshinaga H, et al. Bioorg Med Chem. 2018 May 1;26(8):1614-1627.
2. Kato T, et al. Pharmacol Res Perspect. 2015 Jun;3(3):e00142.
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