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Chemical Structure : DSRM-3716
CAS No.: 58142-99-7
Catalog No.: PC-38164Not For Human Use, Lab Use Only.
DSRM-3716 (DSRM3716, 5-iodoisoquinoline) is a potent and selective inhibitor of NADase SARM1 with IC50 of 75 nM, displays selectivity against various NAD metabolizing and pathway enzymes (e.g., NAMPT and NMNAT).
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| 100 mg | $128 | In stock | |
| 500 mg | $298 | In stock | |
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DSRM-3716 (DSRM3716, 5-iodoisoquinoline) is a potent and selective inhibitor of NADase SARM1 with IC50 of 75 nM.
DSRM-3716 displays selectivity against various NAD metabolizing and pathway enzymes (e.g., NAMPT and NMNAT).
DSRM-3716 recapitulates the SARM1-/- phenotype and protects axons from degeneration induced by axotomy or mitochondrial dysfunction. SARM1 inhibition post-mitochondrial injury with rotenone allows recovery and rescues axons that already entered the metastable state.
DSRM-3716 demontrates the potential to treat axonopathies of the central and peripheral nervous systems by preventing axonal degeneration and by allowing functional recovery of a metastable pool of damaged, but viable, axons.
| M.Wt | 255.058 | |
| Formula | C9H6IN | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-iodoisoquinoline |
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1. Robert O. Hughes, et al. Cell Rep. 2021 Jan 5; 34(1): 108588.
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