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Chemical Structure : DT-061
CAS No.: 1809427-19-7
Catalog No.: PC-70158Not For Human Use, Lab Use Only.
SMAP (DT-061, NZ-8-061) is an orally bioavailable small molecule activator of PP2A, inhibits KRAS-driven tumor growth.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $458 | In stock | |
| 100 mg | $988 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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SMAP (DT-061, NZ-8-061) is an orally bioavailable small molecule activator of PP2A, inhibits KRAS-driven tumor growth; acts by binding to the PP2A Aα scaffold subunit to drive conformational changes in PP2A.
SMAP (DT-061) inhibits the growth of KRAS-mutant lung cancers in mouse xenografts and transgenic models.
| M.Wt | 520.523 | |
| Formula | C25H23F3N2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-((1R,2R,3S)-2-hydroxy-3-(10H-phenoxazin-10-yl)cyclohexyl)-4-(trifluoromethoxy)benzenesulfonamide, rel- |
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1. Sangodkar J, et al. J Clin Invest. 2017 Jun 1;127(6):2081-2090.
2. Kauko O, et al. Sci Transl Med. 2018 Jul 18;10(450). pii: eaaq1093.
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