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Chemical Structure : DX2-201
Catalog No.: PC-20964Not For Human Use, Lab Use Only.
DX2-201 is a potent and selective oxidative phosphorylation (OXPHOS) complex I inhibitor with IC50 of 312 nM in NAD/NADH assays.
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DX2-201 is a potent and selective oxidative phosphorylation (OXPHOS) complex I inhibitor with IC50 of 312 nM in NAD/NADH assays.
DX2-201 potently inhibits the mitochondrial function by depleting ATP production in MIA PaCa-2 cells when glucose is replaced by galactose in the medium, a condition that forces mammalian cells to rely on OXPHOS.
DX2-201 depletes ATP production with an IC50 value of 118.5 nM in the galactose-containing medium.
DX2-201 inhibits MIA PaCa-2 and BxPC-3 cells growth with IC50 values of 0.4 μM and 0.6 μM, respectively.
| M.Wt | 432.55 | |
| Formula | C18H28N2O6S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ding Xue, et al. Ding Xue, et al. J Med Chem. 2022 Jan 13;65(1):343-368.
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