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Chemical Structure : DX3-213B
CAS No.: 2749555-66-4
Catalog No.: PC-38736Not For Human Use, Lab Use Only.
DX3-213B is a potent oxidative phosphorylation (OXPHOS) complex I inhibitor with IC50 of 3.6 nM, inhibits pancreatic cancer cells growth in the low nanomolar range (MIA PaCa-2, GI50=11 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $488 | In stock | |
| 100 mg | Get quote |
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DX3-213B is a potent oxidative phosphorylation (OXPHOS) complex I inhibitor with IC50 of 3.6 nM, inhibits pancreatic cancer cells growth in the low nanomolar range (MIA PaCa-2, GI50=11 nM).
DX3-213B disrupts adenosine triphosphate (ATP) generation (ATP depletion IC50=11 nM), inhibits complex I function.
Oral administration of DX3-213B (10 mg/kg) resulted in significant in vivo efficacy in a pancreatic cancer syngeneic model without obvious toxicity.
| M.Wt | 478.570 | |
| Formula | C20H28F2N2O5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-(4,4-difluoropiperidin-1-yl)(1-((4-(isopropylsulfonyl)phenyl)sulfonyl)piperidin-3-yl)methanone |
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1. Ding Xue, et al. J Med Chem. 2022 Feb 24;65(4):3404-3419.
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