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Chemical Structure : DX3-234
Catalog No.: PC-20780Not For Human Use, Lab Use Only.
DX3-234 is a potent selective complex I oxidative phosphorylation (OXPHOS) inhibitor with IC50 of 42.6 nM in NAD+/NADH assay and IC50 of 29 nM in ATP depletion assay using MIA PaCa-2 cells.
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DX3-234 is a potent selective complex I oxidative phosphorylation (OXPHOS) inhibitor with IC50 of 42.6 nM in NAD+/NADH assay and IC50 of 29 nM in ATP depletion assay using MIA PaCa-2 cells.
DX3-234 inhibits the growth of MIA PaCa-2 cells with an IC50 value of 70 nM.
DX3-234 shows significant tumor suppression in the Pan02 syngeneic model of pancreatic cancer.
| M.Wt | 565.70 | |
| Formula | C25H35N5O6S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ding Xue, et al. J Med Chem. 2022 Jan 13;65(1):343-368.
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