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DZ-837

Chemical Structure : DZ-837

CAS No.: 3105664-95-4

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DZ-837 (DZ837)

Catalog No.: PC-28734Not For Human Use, Lab Use Only.

DZ-837 is an effective BCL6-targeting PROTAC degrader with DC50 values around 600 nM in SU-DHL-4 and DOHH2 cells, effectively inhibits cell growth in BCL6-dependent DLBCL cell lines, exhibits synergistic antiproliferative response and overcame acquired resistance against DLBCL cells combined with Ibrutinib.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DZ-837 is an effective BCL6-targeting PROTAC degrader with DC50 values around 600 nM in SU-DHL-4 and DOHH2 cells, effectively inhibits cell growth in BCL6-dependent DLBCL cell lines, exhibits synergistic antiproliferative response and overcame acquired resistance against DLBCL cells combined with Ibrutinib.

Physicochemical Properties

M.Wt 837.92
Formula C42H44FN9O7S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

5-(1-cyclopentenyl)-N-(4-((2-(4-(2-(2-((2-(2,6-dioxo-3-piperidinyl)-1,3-dioxo-4-isoindolinyl)amino)ethoxy)ethyl)-1-piperazinyl)-5-fluoro-4-pyrimidinyl)amino)-2-methoxyphenyl)thiophene-2-carboxamide

References

1. Dazhao Mi, et al. Eur J Med Chem. 2024 Nov 5:277:116789.

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