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Chemical Structure : DZD8586
Catalog No.: PC-21570Not For Human Use, Lab Use Only.
DZD8586 is an oral, non-covalent, BBB penetrant LYN and BTK dual inhibitor, overcomes resistance mutations to the approved covalent and non-covalent BTK inhibitors.
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DZD8586 is an oral, non-covalent, BBB penetrant LYN and BTK dual inhibitor, overcomes resistance mutations to the approved covalent and non-covalent BTK inhibitors.
DZD8586 exhibits good selectivity against multiple kinases was assessed at Eurofins panel with purified enzymes.
DZD8586 demonstrateS concentration dependent anti-proliferative effects, with similar GI50s among cells carrying different BTK mutations.
DZD8586 exhibitS potent cell growth inhibition and induced cell death in a variety of cell lines in a panel of DLBCL cell lines.
DZD8586 (50 mg/kg) exhibitS profound tumor growth inhibition in a dose-dependent manner, and induces tumor regression in both subcutaneous and CNS tumor models.
| M.Wt | 453.45 | |
| Formula | C23H21F2N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yu Bai, et al. Blood (2023) 142 (Supplement 1): 2822.
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