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Chemical Structure : Danoprevir
CAS No.: 850876-88-9
Catalog No.: PC-42478Not For Human Use, Lab Use Only.
A potent, highly selective, orally available, peptidomimetic HCV NS3/4A protease inhibitor with IC50 of 0.2-0.4 nM (GT1a, 1b, 4, 5 and 6), 1.6 nM (GT2b).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $104 | In stock | |
| 10 mg | $176 | In stock | |
| 50 mg | $512 | In stock |
Bulk size, bulk discount!
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A potent, highly selective, orally available, peptidomimetic HCV NS3/4A protease inhibitor with IC50 of 0.2-0.4 nM (GT1a, 1b, 4, 5 and 6), 1.6 nM (GT2b); shows favorable potency profile against multiple HCV genotypes 1–6 and key mutants (replicon GT1b, EC50=1.6 nM).
HCV Infection
Approved
| M.Wt | 731.8312 | |
| Formula | C35H46FN5O9S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2H-Isoindole-2-carboxylic acid, 4-fluoro-1,3-dihydro-, (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a] |
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1. Bae A, et al. Antimicrob Agents Chemother. 2010 Dec;54(12):5288-97.
2. Moucari R, et al. Gut. 2010 Dec;59(12):1694-8.
3. Jiang Y, et al. J Med Chem. 2014 Mar 13;57(5):1753-69.
4. Schaefer CJ, et al. Antimicrob Agents Chemother. 2011 Jul;55(7):3125-32.
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