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Chemical Structure : Dapagliflozin (2S)-1,2-propanediol hydrate
CAS No.: 960404-48-2
Catalog No.: PC-42593Not For Human Use, Lab Use Only.
A potent, selective, orally active hSGLT2 inhibitor with EC50 of 1.12 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $96 | In stock | |
| 50 mg | $280 | In stock | |
| 100 mg | $360 | In stock |
Bulk size, bulk discount!
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A potent, selective, orally active hSGLT2 inhibitor with EC50 of 1.12 nM; displays >300-fold selectivity over hSGLT1 (EC50=330 nM), highly selectivity versus GLUT transporters; also is a potent selective inhibitor of rSGLT2 (EC50=3 nM), with 200-fold selectivity versus rSGLT1; significantly improves glucose homeostasis, reduces blood glucose levels in hyperglycemic streptozotocin (STZ) rats.
Diabetes
Approved
| M.Wt | 502.9823 | |
| Formula | C24H35ClO9 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-, (1S)-, compd. with (2S)-1,2-propanediol, hydrate (1:1:1) |
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1. Meng W, et al. J Med Chem. 2008 Mar 13;51(5):1145-9.
2. Han S, et al. Diabetes. 2008 Jun;57(6):1723-9.
3. Wilson C. Nat Rev Endocrinol. 2010 Oct;6(10):531.
4. Komoroski B, et al. Clin Pharmacol Ther. 2009 May;85(5):513-9.
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