Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Darexaban
Catalog No.: PC-60995Not For Human Use, Lab Use Only.
A potent, selective and orally available factor Xa (FXa) inhibitor with IC50 of 54.6 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
A potent, selective and orally available factor Xa (FXa) inhibitor with IC50 of 54.6 nM; displays high selectivities over other related serine proteases, such as trypsin, thrombin and kallikrein (IC50>10 uM); demonstrates potent anticoagulant activities both in vitro and in vivo, shows potential for prevention and treatment of thromboembolic diseases.
Thrombosis
Phase 2 Discontinued
| M.Wt | 474.561 | |
| Formula | C27H30N4O4 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Hirayama F, et al. J Med Chem. 2011 Dec 8;54(23):8051-65.
2. Iwatsuki Y, Eur J Pharmacol. 2011 Dec 30;673(1-3):49-55.
3. Funatsu T, et al. J Thromb Haemost. 2012 Apr;10(4):703-5.
4. Steg PG, et al. Eur Heart J. 2011 Oct;32(20):2541-54.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
