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Chemical Structure : Dazucorilant
Catalog No.: PC-38386Not For Human Use, Lab Use Only.
Dazucorilant (CORT113176) is a potent, selective glucocorticoid receptor (GR) modulator with Ki of < 1 nM, with low or null affinity for other steroid receptors.
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Dazucorilant (CORT113176) is a potent, selective glucocorticoid receptor (GR) modulator with Ki of < 1 nM, with low or null affinity for other steroid receptors.
Dazucorilant (CORT113176) reverses hippocampal amyloid-β peptide generation, neuroinflammation, and apoptotic processes, restores the hippocampal levels of synaptic markers, re-establishes basal plasma levels of glucocorticoids, and improves cognitive function in vivo.
Dazucorilant (CORT113176) reversed the abnormalities of motoneurons and down-regulated proinflammatory mediators, prevented neuropathology and showed anti-inflammatory and anti-glutamatergic effects in the spinal cord of Wobbler mice.
Dazucorilant (CORT113176) also selectively reduced binge-like EtOH intake and BECs in the HDID-1 mice.
| M.Wt | 582.574 | |
| Formula | C29H22F4N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Pineau F, et al. Neurobiol Aging. 2016 Sep;45:109-122.
2. Meyer M, et al. Brain Res. 2020 Jan 15;1727:146551.
3. Savarese AM, et al. Alcohol Clin Exp Res. 2020 May;44(5):1025-1036.
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