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Cat. No. Product Name CAS No. Information
PC-63143

AZD-7594

1196509-60-0

AZD-7594 (AZ-13189620) is a potent, nonsteroidal, selective glucocorticoid receptor modulator (SGRM) with binding IC50 of 0.9 nM, shows no affinity for AR, PR, MR and ERα/β; demonstrates cell potentcy with IC50 of 55 nM (repression of AP-1 dependent transcription), inhibits LPS-stimulated TNF-α production in human PBMC with IC50 0.43 nM; potently inhibits lung edema in a rat model of allergic airway inflammation with inhaled EC50 of 130 uM/Kg.

Asthma

Phase 2 Clinical

PC-61653

CORT 118335

1400902-13-7

CORT 118335 (Miricorilant, C118335) is a novel potent, selective, non-steroidal glucocorticoid receptor (GR) antagonist with Ki of 8 nM, shows modest affinity for MR; exhibits in vivo efficacy in the olanzapine-induced weight gain model in rats; can also block GR activity in prostate cancer and slows CRPC progression both in vitro and in vivo.

PC-61603

Mapracorat

887375-26-0

Mapracorat (ZK 245186) is a potent, selective and non-steroid glucocorticoid receptor (GR) agonist with binding Ki of 1.9 nM; does not show significant activity for ERα, PR, AR or MR; shows anti-inflammatory efficacy after topical application similar to the classical glucocorticoids, with a better safety profile.

Psoriasis

Phase 1 Clinical

PC-60801

LLY-2707

1621865-33-5

LLY-2707 (LLY 2707, LLY2707) is a novel potent, selective, nonsteroidal glucocorticoid receptor antagonist with Ki of 2.13 nM; shows substantially lower potency at the other steroid receptors (AR, MR and PR); suppress amphetamine-induced increases in locomotor activity, reduces atypical antipsychotic-associated weight gain in rats.

PC-60072

AZD-9567 monohydrate

1893415-64-9

AZD-9567 monohydrate is a potent, selective, non-steroidal and orally available selective glucocorticoid receptor modulator (SGRM) for treatment of rheumatoid arthritis.

Rheumatoid Arthritis

Phase 2 Clinical

PC-60071

AZD-9567

1893415-00-3

AZD-9567 (AZD9567) is a potent, selective, non-steroidal and orally available selective glucocorticoid receptor modulator (SGRM) for treatment of rheumatoid arthritis.

Rheumatoid Arthritis

Phase 2 Clinical

PC-45178

Loteprednol etabonate

82034-46-6

Loteprednol etabonate is an anti-inflammatory corticosteroid used in optometry and ophthalmology.

Allergy

Approved

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