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Chemical Structure : DeFer-2
Catalog No.: PC-20653Not For Human Use, Lab Use Only.
DeFer-2 is an oleic acid (OA)-based ferritin-targeting PROTAC binding Kd of 17.1 uM, degrades ferritin and rapidly elevates the free iron content, induces pyroptosis.
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DeFer-2 is an oleic acid (OA)-based ferritin-targeting PROTAC binding Kd of 17.1 uM, degrades ferritin and rapidly elevates the free iron content, induces pyroptosis.
DeFer-2 caused the caspase 3-GSDME-mediated pyroptosis in cancer cells rather than typical ferroptosis, which is always associated with iron ion overload.
DeFer-2 (tailored albumin-based nano-formulation) substantially inhibited tumor growth and prolonged the survival time of mice bearing B16F10 subcutaneous tumors with negligible adverse effects.
| M.Wt | 780.13 | |
| Formula | C44H69N5O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yu Chen, et al. Journal of the American Chemical Society, April 24, 2023
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