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Chemical Structure : Debio 0930
CAS No.: 1179347-65-9
Catalog No.: PC-38548Not For Human Use, Lab Use Only.
Debio 0930 (MY 63-78) is a specific and potent direct AMPK activator, allosterically activates AMPK activity in prostate cancer cells with EC50 of 25 uM, without altering the energy levels.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $348 | In stock | |
| 100 mg | Get quote |
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Debio 0930 (MY 63-78) is a specific and potent direct AMPK activator, allosterically activates AMPK activity in prostate cancer cells with EC50 of 25 uM, without altering the energy levels.
MT 63-78 activates AMPK mainly by binding the β1 subunit in a cell-based context, LKB1 is not essential for MT 63-78-mediated activation of AMPK.
MT 63-78 inhibits PCa cell growth and soft agar colony formation, induces mitotic arrest and apoptosis.
MT 63-78 enhances the growth inhibitory effect of AR signaling inhibitors, inhibits tumor growth in xenograft models.
| M.Wt | 326.355 | |
| Formula | C21H14N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-(2′,6′-Dihydroxy[1,1′-biphenyl]-4-yl)-1H-indole-3-carbonitrile |
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1. Giorgia Zadra, et al. EMBO Mol Med. 2014 Apr;6(4):519-38.
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