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Devimistat

Chemical Structure : Devimistat

CAS No.: 95809-78-2

Devimistat (CPI-613)

Catalog No.: PC-38723Not For Human Use, Lab Use Only.

CPI-613 (Devimistat) is an antimitochondrial metabolism agent that specifically induces inactivating phosphorylation of tumor cell PDH via stimulation of PDKs 1 to 4, inhibits KGDH function strongly and rapidly, selectively in tumor cells.

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Biological Activity

CPI-613 (Devimistat) is an antimitochondrial metabolism agent that specifically induces inactivating phosphorylation of tumor cell PDH via stimulation of PDKs 1 to 4, inhibits KGDH function strongly and rapidly, selectively in tumor cells.
CPI-613 down-regulated the expression of Cyclin D3, E1, E2, F, A2, B1 and CDK2 genes of BxPC-3 pancreatic cancer cells but not non-transformed NIH-3T3 mouse fibroblast cells.
CPI-613 induced a correspondingly rapid, powerful redox signal in tumor cell mitochondria.
CPI-613 demonstrated tumor growth inhibition in human xenograft mouse models.

Physicochemical Properties

M.Wt 388.584
Formula C22H28O2S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

6,8-bis[(phenylmethyl)thio]-octanoic acid

References

1. Stuart SD, et al. Cancer Metab. 2014 Mar 10;2(1):4.

2. Pardee TS, et al. Clin Cancer Res. 2014 Oct 15;20(20):5255-64.

3. Lee KC, et al. Ann Transl Med. 2014 Sep;2(9):91.

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