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Dexmedetomidine

Chemical Structure : Dexmedetomidine

CAS No.: 113775-47-6

Dexmedetomidine ((+)-Medetomidine, (S)-Medetomidine)

Catalog No.: PC-27361Not For Human Use, Lab Use Only.

Dexmedetomidine is a potent, selective agonist of α2-adrenergic receptor (α2-adrenoceptor) with Ki of 1.08 nM, >1000-fold selectivity against α1-adrenoceptor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Dexmedetomidine is a potent, selective agonist of α2-adrenergic receptor (α2-adrenoceptor) with Ki of 1.08 nM, >1000-fold selectivity against α1-adrenoceptor.
Dexmedetomidine is used in veterinary medicine for its analgesic and sedative properties.
Dexmedetomidine also protects against lung injury induced by ischemia-reperfusion through inhibition of autophagy in rats.

Physicochemical Properties

M.Wt 200.29
Formula C13H16N2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1H-Imidazole, 5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-

References

1. Cormack JR, et al. J Clin Neurosci. 2005 May;12(4):375-8.

2. Luo C, et al. Front Cell Neurosci. 2017 Jul 6;11:197.

3. Zhang W, et al. Exp Ther Med. 2017 Aug;14(2):973-980.

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