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Chemical Structure : Diethyl-pythiDC
CAS No.: 1821370-70-0
Catalog No.: PC-72921Not For Human Use, Lab Use Only.
Diethyl-pythiDC (diethyl pythiDC) is a selective, small molecule inhibitor of P4HA1, inhibits collagen biosynthesis in breast cancer cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $168 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote |
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Diethyl-pythiDC (diethyl pythiDC) is a selective, small molecule inhibitor of P4HA1, inhibits collagen biosynthesis in breast cancer cells.
diethyl-pythiDC decreased levels of AGO2 in CRC cells, also reduced the malignant phenotypes of CRC cells, including cell proliferation, colony formation, invasion and spheroid-forming capacity.
diethyl-pythiDC (100 mg/kg) reduced growth in a CRC PDX model through the P4HA1 downstream targets, MMP1 and AGO2.
The prolyl-4-hydroxylase enzymes prolyl 4-hydroxylase, alpha polypeptide I (P4HA1), P4HA2, and P4HB are necessary for collagen synthesis and deposition; matrix metalloproteinases degrade collagen, P4HA1 catalyzes the formation of 4-hydroxyproline from proline residues, a process that is essential for the proper folding of collagen polypeptide chains into stable triple-helical molecules.
| M.Wt | 306.336 | |
| Formula | C14H14N2O4S | |
| Appearance | Solid | |
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| Chemical Name/SMILES |
6-(5-ethoxycarbonyl-thiazol-2-yl)-nicotinic acid ethyl ester |
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1. James D Vasta, et al. ACS Chem Biol. 2016 Jan 15;11(1):193-9.
2. Sumit Agarwal, et al. Transl Oncol. 2020 Apr;13(4):100754.
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