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Chemical Structure : Difluorophenyl Quinazoline
Catalog No.: PC-20987Not For Human Use, Lab Use Only.
Difluorophenyl Quinazoline (DFPQ, AP-06-202) is a selective, biased, negative allosteric modulator of β-arrestin recruitment to the β2AR, without effect on on β2AR coupling to Gs.
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Difluorophenyl Quinazoline (DFPQ, AP-06-202) is a selective, biased, negative allosteric modulator of β-arrestin recruitment to β2-adrenergic receptor (β2AR), without effect on on β2AR coupling to Gs.
DFPQ effectively inhibits agonist-promoted phosphorylation and internalization of the β2AR and protects against the functional desensitization of β-agonist mediated regulation in cell and tissue models.
Difluorophenyl Quinazoline (DFPQ) also is specific to the β2AR with minimal effects on the β1AR.
| M.Wt | 354.40 | |
| Formula | C20H20F2N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ippolito M, et al. Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2302668120.
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