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Dihydroberberine

Chemical Structure : Dihydroberberine

CAS No.: 483-15-8

Dihydroberberine (dhBBR)

Catalog No.: PC-27255Not For Human Use, Lab Use Only.

Dihydroberberine (dhBBR) is a berberine derivative that inhibit mitochondrial respiratory complex I, improves whole-body insulin sensitivity through increased AMPK activity, exhibits synergistic effects with sunitinib on NSCLC NCI-H460 cells by repressing MAP kinase pathways.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Dihydroberberine (dhBBR) is a berberine derivative that inhibit mitochondrial respiratory complex I, improves whole-body insulin sensitivity through increased AMPK activity, exhibits synergistic effects with sunitinib on NSCLC NCI-H460 cells by repressing MAP kinase pathways.

Physicochemical Properties

M.Wt 337.38
Formula C20H19NO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

9,10-Dimethoxy-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline

References

1. Turner N, et al. Diabetes. 2008 May;57(5):1414-8.

2. Liu DL, et al. Chin J Integr Med. 2015 Feb;21(2):132-8.

3. Xu L, et al. Front Pharmacol. 2021 Apr 20;12:645879.

4. Dai B, et al. J Cell Mol Med. 2017 Oct;21(10):2573-2585.

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