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Chemical Structure : Dihydromunduletone
CAS No.: 674786-20-0
Catalog No.: PC-60594Not For Human Use, Lab Use Only.
Dihydromunduletone is a rotenoid derivative that selectively inhibits GPR56 (IC50=21 uM) and GPR114/ADGRG5, but not GPR110 or Class A GPCRs.
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Dihydromunduletone is a rotenoid derivative that selectively inhibits GPR56 (IC50=21 uM) and GPR114/ADGRG5, but not GPR110 or Class A GPCRs.
Dihydromunduletone maximally inhibits GPR56 at 50 uM, also dramatically inhibits GPR114 7TM–stimulated Gs activity.
Dihydromunduletone also inhibit the growth of the zebrafish intersegmental vessels.
| M.Wt | 424.493 | |
| Formula | C25H28O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(3,4-Dihydro-3,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-2-(5-methoxy-2,2-dimethyl-2H-1-benzopyran-6-yl)ethanone |
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1. Stoveken HM, et al. Mol Pharmacol. 2016 Sep;90(3):214-24.
2. Wang C, et al. Eur Urol. 2010 Sep;58(3):418-26.
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