DnAurA-A10

Chemical Structure : DnAurA-A10

Catalog No.: PC-27878Not For Human Use, Lab Use Only.

DnAurA-A10 is a selective, nuclear-targeted PROTAC degrader of Aurora kinase A (AURKA), induces nuclear AURKA degradation at 10-50 uM in HCT116 cells.

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Biological Activity

DnAurA-A10 is a selective, nuclear-targeted PROTAC degrader of Aurora kinase A (AURKA), induces nuclear AURKA degradation at 10-50 uM in HCT116 cells.

Physicochemical Properties

M.Wt	1228.95
Formula	C70H83ClFN11O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(10-(4-((2,5-bis(4-(pyrrolidin-1-yl)piperidine-1-carbonyl)phenyl)amino)benzamido)decyl)-4-((9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[c]pyrimido[4,5-e]azepin-2-yl)amino)-2-methoxybenzamide

References

1. Bowen Qian, et al. Biochem Biophys Res Commun. 2026 Aug 18:834:154458.

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DnAurA-A10

Biological Activity

Physicochemical Properties

References

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