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Chemical Structure : Dorsomorphin
CAS No.: 866405-64-3
Catalog No.: PC-43522Not For Human Use, Lab Use Only.
Dorsomorphin (BML-275, Compound C) is a potent, selective and reversible AMPK inhibitor with Ki of 109 nM, shows no no significant activity on ZAPK, SYK, PKCθ, PKA and JAK3.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $488 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Dorsomorphin (BML-275, Compound C) is a potent, selective and reversible AMPK inhibitor with Ki of 109 nM, shows no no significant activity on ZAPK, SYK, PKCθ, PKA and JAK3.
Dorsomorphin (BML-275, Compound C) inhibits AMPK activation induced by AICAR and Metformin, also inhibits bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6).
Dorsomorphin (BML-275, Compound C)promotes cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro, induces autophagy in cancer cell lines via a mechanism independent of AMPK inhibition.
| M.Wt | ||
| Formula | C24H25N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Pyrazolo[1,5-a]pyrimidine, 6-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)- |
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1. Yu PB, et al. Nat Chem Biol. 2008 Jan;4(1):33-41.
2. Vucicevic L, et al. Autophagy. 2011 Jan;7(1):40-50.
3. Diekmann U, et al. Stem Cells Dev. 2015 Jan 15;24(2):190-204.
4. Zhou G, et al. J Clin Invest. 2001 Oct;108(8):1167-74.
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