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Chemical Structure : E-7050
CAS No.: 928037-13-2
Catalog No.: PC-43372Not For Human Use, Lab Use Only.
E-7050 (Golvatinib) is a potent, dual c-Met and VEGFR-2 tyrosine kinase inhibitor with IC50 of 14 and 16 nM (kinase phosphorylation inhibition).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $58 | In stock | |
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | Get quote |
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E-7050 (Golvatinib) is a potent, dual c-Met and VEGFR-2 tyrosine kinase inhibitor with IC50 of 14 and 16 nM (kinase phosphorylation inhibition).
E-7050 (Golvatinib) also strongly inhibits the growth of MKN45, EBC-1, Hs746T, and SNU-5 tumor cells with IC50 values of 37, 6.2, 23, and 24 nM, respectively.
E-7050 (Golvatinib) selectively inhibits the growth of the c-Met amplified tumor cell lines in vitro.
E-7050 (Golvatinib) specifically inhibits HGF and VEGF stimulated HUVEC growth with IC50 values of 17 nM and 84 nM respectively, but bFGF stimulated HUVEC.
E-7050 (Golvatinib) demonstrates inhibition of the phosphorylation of c-Met and VEGFR-2 in tumors, and strong inhibition of tumor growth and tumor angiogenesis in xenograft models.
| M.Wt | 633.6882 | |
| Formula | C33H37F2N7O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1,1-Cyclopropanedicarboxamide, N-[2-fluoro-4-[[2-[[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]amino]-4-pyridinyl]oxy]phenyl]-N'-(4-fluorophenyl)- |
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1. Nakagawa T, et al. Cancer Sci. 2010 Jan;101(1):210-5.
2. Wang W, et al. Clin Cancer Res. 2012 Mar 15;18(6):1663-71.
3. Nakagawa T, et al. Mol Cancer Ther. 2012 Oct;11(10):2149-57.
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