Chemical Structure : E0714
CAS No.:
1359358-36-3
E0714
(E-0714)
Catalog No.: PC-26103Not For Human Use, Lab Use Only.
E0714 (E-0714) is a potent, specific agonist of Kv7.2 potassium channel (KCNQ2) with EC50 of 1.9 uM and 0.021 uM for Kv7.2 and Kv7.2/7.3 currents, with no significant activation of Kv7.1/7.3/7.4/7.5.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
E0714 (E-0714) is a potent, specific agonist of Kv7.2 potassium channel (KCNQ2) with EC50 of 1.9 uM and 0.021 uM for Kv7.2 and Kv7.2/7.3 currents, with no significant activation of Kv7.1/7.3/7.4/7.5.
E0714 targets the Kv7.2-specific residues F112, Y118, and N289, which are responsible for the compound's subtype-selective activation.
E0714 demonstrated potent antiepileptic activity in classic seizure models, including pentylenetetrazol (PTZ)-induced seizure model, maximal electroshock (MES) model and 6 Hz electrical stimulation model.
E0714 did not impair motor coordination in mice in the rotarod test.
Physicochemical Properties
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M.Wt
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347.37
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Formula
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C20H17N3O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-(4-Benzamidophenyl)-N-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
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References
1. Qiao K, et al. J Med Chem. 2026 Feb 19. doi: 10.1021/acs.jmedchem.5c03052.
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