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Chemical Structure : E260
Catalog No.: PC-62649Not For Human Use, Lab Use Only.
E260 is a novel inhibitor of the Fer/FerT kinase with Kd of 0.85 uM, selectively evokes metabolic stress and necrotic death in cancer cells.
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E260 is a novel inhibitor of the Fer/FerT kinase with Kd of 0.85 uM, selectively evokes metabolic stress and necrotic death in cancer cells; compromises mitochondrial integrity, and activates PARP-1 and autophagy, thereby targeting the energy management system of cancer cells; exhibits an viability EC50 of 400 nM after 24 h of treatment and an EC50 of 300 nM after 48 h in metastatic SW620 cells; suppresses xenografts progression in vivo.
| M.Wt | 438.638 | |
| Formula | C24H34N6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Elkis Y, et al. Nat Commun. 2017 Oct 16;8(1):940.
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