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Chemical Structure : EBP inhibitor 11
Catalog No.: PC-21945Not For Human Use, Lab Use Only.
EBP inhibitor 11 is a potent, selective, brain-penetrant, orally bioavailable inhibitor of emopamil binding protein (EBP) with mGCMS zymo EC50 of 8 nM, and OPC differentiation EC50 of 44 nM.
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EBP inhibitor 11 is a potent, selective, brain-penetrant, orally bioavailable inhibitor of emopamil binding protein (EBP) with mGCMS zymo EC50 of 8 nM, and OPC differentiation EC50 of 44 nM.
EBP inhibitor 11 exhibits EC50 of 39 nM in hGCMS cellular assays.
EBP inhibitor 11 demonstrates strong in vivo target engagement in the brain, as illustrated by the accumulation of EBP substrate zymostenol after repeated dosing.
| M.Wt | 411.55 | |
| Formula | C24H33N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ruth Dorel, et al. J Med Chem. 2024 Mar 12. doi: 10.1021/acs.jmedchem.3c02396.
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