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Chemical Structure : EED226
CAS No.: 2083627-02-3
Catalog No.: PC-42321Not For Human Use, Lab Use Only.
EED226 (EED 226) is a potent, selective, orally bioavailable PRC2 inhibitor that directly binds to the H3K27me3 binding pocket of EED (IC50=22 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | $358 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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EED226 (EED 226) is a potent, selective, orally bioavailable PRC2 inhibitor that directly binds to the H3K27me3 binding pocket of EED (IC50=22 nM).
EED226 shows remarkable selectivity over 21 other PRMTs, with one exception EZH1.
EED226 potently reduces global H3K27Me3 mark in cells and demonstrates selectively cell killing effects in cells carrying a heterozygous Y641N mutation.
EED226 induces robust and sustained tumor regression in EZH2MUT pre-clinical DLBCL model.
| M.Wt | 369.3977 | |
| Formula | C17H15N5O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 29 mg/mL |
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| Chemical Name/SMILES |
1,2,4-Triazolo[4,3-c]pyrimidin-5-amine, N-(2-furanylmethyl)-8-[4-(methylsulfonyl)phenyl]- |
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1. Qi W, et al. Nat Chem Biol. 2017 Apr;13(4):381-388.
2. Huang Y, et al. J Med Chem. 2017 Mar 23;60(6):2215-2226.
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