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Chemical Structure : ELOVL6 inhibitor 37
CAS No.: 1067647-43-1
Catalog No.: PC-20305Not For Human Use, Lab Use Only.
ELOVL6 inhibitor 37 is a potent, selective inhibitor of elongase of long-chain fatty acids family 6 (ELOVL6) with IC50 of 8.9 and 31 nM for human and mouse ELOVL6, respectively.
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|---|---|---|---|
| 5 mg | $288 | In stock | |
| 25 mg | $598 | In stock | |
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| 200 mg | Get quote | ||
| 1 g | Get quote |
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ELOVL6 inhibitor 37 is a potent, selective inhibitor of elongase of long-chain fatty acids family 6 (ELOVL6) with IC50 of 8.9 and 31 nM for human and mouse ELOVL6, respectively.
ELOVL6 inhibitor 37 weakly inhibits hELOVL3 (IC50=337 nM), and does not inhibit hELOVL1, hELOVL2 and hELOVL5 (IC50>10 uM).
ELOVL6 inhibitor 37 (0.1, 0.3, and 1 mg/kg, 0.5% methylcellulose, oral) potently and dose-proportionally suppressed the elongation index in the liver in mice.
| M.Wt | 579.50 | |
| Formula | C28H23F6N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5,5-dimethyl-3-(5-methyl-3-oxo-2-(4-(trifluoromethoxy)phenyl)-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione |
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1. Toshiyuki Takahashi, et al. J Med Chem. 2009 May 28;52(10):3142-5.
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