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Chemical Structure : ELOVL6 inhibitor Compound A
CAS No.: 1185736-98-4
Catalog No.: PC-20304Not For Human Use, Lab Use Only.
ELOVL6 inhibitor Compound-A is a potent, selective inhibitor of elongase of long-chain fatty acids family 6 (ELOVL6) with IC50 of 169 and 350 nM for human and mouse ELOVL6, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $288 | In stock | |
| 25 mg | $598 | In stock | |
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| 200 mg | Get quote | ||
| 1 g | Get quote |
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ELOVL6 inhibitor Compound-A is a potent, selective inhibitor of elongase of long-chain fatty acids family 6 (ELOVL6) with IC50 of 169 and 350 nM for human and mouse ELOVL6, respectively.
Compound-A displays >30-fold selectivity over recombinant human ELOVL family enzymes (ELOVL1, -2, -3, and -5, IC50 values >5-10 uM), also shows negligible or very weak inhibitory effects on rat microsomal SCD, human ACC1 and -2, and human FAS.
Compound-A inhibits ELOVL6 in a noncompetitive manner for malonyl-CoA (Ki=994 nM) and in an uncompetitive manner for palmitoyl-CoA.
Compound-A effectively reduced the elongation index of fatty acids of hepatocytes.
Compound-A (100 mg/kg, oral) significantly reduced the elongation index of the total fatty acids of the liver in mice.
| M.Wt | 495.50 | |
| Formula | C27H24F3N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5,5-dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione |
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1. Ken Shimamura, et al. J Pharmacol Exp Ther. 2009 Jul;330(1):249-56.
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