EN020 | TREM2 modulator | Probechem Biochemicals

Chemical Structure : EN020

EN020 (EN-020)

Catalog No.: PC-25437Not For Human Use, Lab Use Only.

EN020 is a novel small molecule modulator of triggering receptor expressed on myeloid cells 2 (TREM2) with KD of 14.2 µM (MST) and 35.9 µM (SPR), significantly enhances microglial phagocytosis in BV2 cells.

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Biological Activity

Physicochemical Properties

M.Wt	318.72
Formula	C14H11ClN4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-chloropyridin-3-yl 2-(5-methyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)acetate

References

1. Sungwoo Cho, et al. bioRxiv [Preprint]. 2025 Aug 28:2025.08.23.671917.

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EN020 (EN-020)

Biological Activity

Physicochemical Properties

References

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