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Chemical Structure : EN460
CAS No.: 496807-64-8
Catalog No.: PC-43248Not For Human Use, Lab Use Only.
EN460 is a specific mall molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1), interacts selectively with the reduced, active form of ERO1α and prevents its reoxidation (IC50=1.9 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | $588 | In stock | |
| 100 mg | Get quote |
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EN460 is a specific mall molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1), interacts selectively with the reduced, active form of ERO1α and prevents its reoxidation (IC50=1.9 uM).
EN460 promotes signaling in the unfolded protein response and precondition cells against severe ER stress.
EN460 shows a dose response effect on the embryos with a dose of 10 uM being significantly lethal during early embryonic development.
| M.Wt | 460.7899 | |
| Formula | C22H12ClF3N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzoic acid, 2-chloro-5-[4,5-dihydro-5-oxo-4-[(5-phenyl-2-furanyl)methylene]-3-(trifluoromethyl)-1H-pyrazol-1-yl]- |
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1. Blais JD, et al. J Biol Chem. 2010 Jul 2;285(27):20993-1003.
2. Geldenhuys WJ, et al. Bioorg Med Chem Lett. 2017 May 1;27(9):2029-2037.
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