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ENT1-IN-39

Chemical Structure : ENT1-IN-39

CAS No.: 2097508-70-6

ENT1-IN-39 (ENT-1 inhibitor)

Catalog No.: PC-60154Not For Human Use, Lab Use Only.

A potent adenosine transport activity of ENT-1 with IC50 of 26.9 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A potent adenosine transport activity of ENT-1 with IC50 of 26.9 nM; displays ENT1 inhibition and efficacy in L-687414-induced hyperlocomotion mouse model (99.5 inhibition at 30 mg/kg, i.p.)

Physicochemical Properties

M.Wt 427.508
Formula C25H25N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

6-(3,3-dimethyl-6-(2-methylpyrimidin-5-yl)-2-oxoindolin-1-yl)-1,3,3-trimethyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one

References

1. Gerard Rosse. ACS Med. Chem. Lett., 2017, 8 (10), pp 995-996.

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