Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : EPZ-719
Catalog No.: PC-72317Not For Human Use, Lab Use Only.
EPZ-719 (EPZ 719) is a potent, selective SETD2 histone methyltransferase inhibitor with IC50 of 8 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
EPZ-719 (EPZ 719) is a potent, selective SETD2 histone methyltransferase inhibitor with IC50 of 8 nM.
EPZ-719 displayed a >8000-fold selectivity in a panel of 14 other histone methyltransferases, showing a remarkable level of selectivity over these closely related and potentially confounding targets.
EPZ-719 demonstrated the activity in a cellular context using an in-cell Western (ICW) cell biochemical assay in A549 cells by monitoring the H3K36 trimethyl mark with IC50 of 23 nM.
EPZ-719 potent antiproliferative activity against multiple myeloma cell lines, KMS34 and KMS1, with LTP day 14 IC50 of 25 nM and 211 nM.
EPZ-719 is an attractive tool compound for the interrogation of SETD2 biology that enables in vivo target validation studies.
| M.Wt | 450.573 | |
| Formula | C22H31FN4O3S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
|
|
1. John W Lampe, et al. ACS Med Chem Lett. 2021 Aug 24;12(10):1539-1545.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
