Catalog No.: PC-26076Not For Human Use, Lab Use Only.
ERX-208 is a small molecule ERX-41 analog that binds stereospecifically to lysosomal acid lipase A (LIPA), induces endoplasmic reticulum stress (ERS) and apoptosis in a panel of OCa cell lines in vitro (IC50=100 nM).
ERX-208 is a small molecule ERX-41 analog that binds stereospecifically to lysosomal acid lipase A (LIPA), induces endoplasmic reticulum stress (ERS) and apoptosis in a panel of OCa cell lines in vitro (IC50=100 nM).
ERX-208 induces caspase-dependent apoptosis in treated ES2 OCa cells.
RX-208 significantly reduced viability in SKOV3 and OVCAR4 cells, with an IC₅₀ of ~100 nM, representing a five-fold increase in potency compared to ERX-41 (IC₅₀ ~500 nM), ERX-208 exhibited minimal cytotoxicity in immortalized normal ovarian surface epithelial (IOSE) cells.
ERX-208 induces endoplasmic reticulum stress in ovarian cancer cells (OCa).
ERX-208-mediated ERS response is dependent on LIPA expression.
ERX-208 (5-10 mg/kg, i.p.) exerts potent antitumor activity on OCa-30 PDX tumor models, potently reduces the growth of PDE and orthotopic ES2-CDX tumors, suppresses metastasis.
