Chemical Structure : ERX-208
CAS No.:
2440087-57-8
ERX-208
(ERX208)
Catalog No.: PC-26076Not For Human Use, Lab Use Only.
ERX-208 is a small molecule ERX-41 analog that binds stereospecifically to lysosomal acid lipase A (LIPA), induces endoplasmic reticulum stress (ERS) and apoptosis in a panel of OCa cell lines in vitro (IC50=100 nM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ERX-208 is a small molecule ERX-41 analog that binds stereospecifically to lysosomal acid lipase A (LIPA), induces endoplasmic reticulum stress (ERS) and apoptosis in a panel of OCa cell lines in vitro (IC50=100 nM).
ERX-208 induces caspase-dependent apoptosis in treated ES2 OCa cells.
RX-208 significantly reduced viability in SKOV3 and OVCAR4 cells, with an IC₅₀ of ~100 nM, representing a five-fold increase in potency compared to ERX-41 (IC₅₀ ~500 nM), ERX-208 exhibited minimal cytotoxicity in immortalized normal ovarian surface epithelial (IOSE) cells.
ERX-208 induces endoplasmic reticulum stress in ovarian cancer cells (OCa).
ERX-208-mediated ERS response is dependent on LIPA expression.
ERX-208 (5-10 mg/kg, i.p.) exerts potent antitumor activity on OCa-30 PDX tumor models, potently reduces the growth of PDE and orthotopic ES2-CDX tumors, suppresses metastasis.
Physicochemical Properties
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M.Wt
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860.97
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Formula
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C47H52N6O10
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-(2-hydroxyethoxy)-N-(2-isobutoxy-4-((2-isobutoxy-4-(((1r,4r)-4-(quinolin-3-ylcarbamoyl)cyclohexyl)carbamoyl)phenyl)carbamoyl)phenyl)-4-nitrobenzamide
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References
1. Viswanadhapalli S, et al. Oncogene. 2026 Feb 6. doi: 10.1038/s41388-026-03689-w.
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