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Chemical Structure : ERX-41
Catalog No.: PC-38797Not For Human Use, Lab Use Only.
ERX-41 is a small molecule that binds to lysosomal acid lipase A (LIPA), and induces endoplasmic reticulum (ER) stress resulting in cell death, blocks proliferation of ER-α⁺ BC cells and TNBC cells in vitro.
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ERX-41 is a small molecule that binds to lysosomal acid lipase A (LIPA), and induces endoplasmic reticulum (ER) stress resulting in cell death, blocks proliferation of ER-α⁺ BC cells and TNBC cells in vitro.
ERX-41 activity is independent of LIPA lipase function but dependent on its ER localization.
ERX-41 binding of LIPA decreases expression of multiple ER-resident proteins involved in protein folding.
ERX-41 shows no adverse effects either on normal mammary epithelial cells or in mice.
| M.Wt | 704.821 | |
| Formula | C38H48N4O9 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Liu X, et al. Nat Cancer. 2022 Jun 2. doi: 10.1038/s43018-022-00389-8.
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