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ES9-17

Chemical Structure : ES9-17

CAS No.: 55854-43-8

ES9-17 (Clathrin inhibitor ES9-17)

Catalog No.: PC-72983Not For Human Use, Lab Use Only.

ES9-17 is a non-protonophoric, improved Endosidin9 (ES9) analog that inhibits clathrin heavy chain (CHC) function in both Arabidopsis and human cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ES9-17 is a non-protonophoric, improved Endosidin9 (ES9) analog that inhibits clathrin heavy chain (CHC) function in both Arabidopsis and human cells.
ES9-17 inhibits transferrin uptake in HeLa cells with EC50 of 17.2 uM.
ES9-17 inhibits clathrin heavy chain (CHC) function in both Arabidopsis and human cells through affinity-based target isolation in vitro binding studies.

Physicochemical Properties

M.Wt 318.203
Formula C10H8BrNO2S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-bromo-N-phenylthiophene-2-sulfonamide

References

1. Dejonghe W, et al. Nat Chem Biol. 2019 Jun;15(6):641-649.

2. Dejonghe W, et al. Nat Commun. 2016 Jun 8;7:11710.

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