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AK306 is a small molecule clathrin heavy chain (CLTC/CHC) binding compound that induces arrest and apoptosis of the HCT116 colon cancer cell line with EC50 of 50 nM; demonstrates broad spectrum activity against of cancer cell lines with total growth inhibition values ranging from ~25 nM to 25 uM; disrupts Aurora A localization, leading to the formation of multiple foci, induces a p53-dependent cell death, and centrosome disruption.


Pitstop 2

1419093-54-1 A small molecule inhibitor of clathrin terminal domain and inhibits clathrin-mediated endocytosis; inhibits endocytosis of transferrin receptor, a CDE cargo protein, but not affect endocytosis of shiga toxin; traps HeLa cells in metaphase through loss of mitotic spindle integrity and activation of the spindle assembly checkpoint, a useful tool for investigating clathrin spindle dynamics.

Pitstop 1

1332879-51-2 A potent, selective inhibitor of clathrin-independent endocytosis with IC50 of 18 uM (inhibition of clathrin TD-amphiphysin B/C complex formation); inhibits endocytic recycling of synaptic vesicles in neurons and in situ.

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